Apurímac, Peru is located in the southern Andes of Peru and his home to many villages and towns characterized by uncommercialized natural beauty. In addition to natural beauty, the cities of Abancay and Andahuaylas, are home to Spanish colonial architecture each with a main square and narrow cobblestone streets. The main tourist activities in this area are hiking and white water rafting. Agencies are available to organize such activities. Since the regions proximity to the city of Cusco, many tourists make offshoot trips from Cusco to Apurimac.

Arequipa, Peru is one of the most geographically, culturally, and socially varied of Peru. Main attractions of the department are the city of Arequipa, the Colca Canyon, adventure tourism, and wildlife observation. The city of Arequipa, the second largest in the nation after Lima, is known as the white city. The name comes from the white colour of the city's buildings which are made of a white stone called sillar which comes from the volcanoes in the area. The city is overshadowed by the El Misti volcano which adds to the city's charm. It is the most developed city in Peru after Lima. The Historic centre of Arequipa was placed on the UNESCO World Heritage Site by the United Nations for its abundance of baroque colonial churches and mansions, and the Santa Catalina Monastery, a city within a city with cobblestone roads, plazas, and patios. Arequipan cuisine is among the best in Peru and has spread throughout the country and the globe. The Colca Canyon is located 100 miles northwest of Arequipa and is double in depth as the Grand Canyon of the United States. The Cotahuasi Canyon, located nearer to the city but considered less picturesque is the deepest in the Western Hemisphere.

Ayacucho, Peru is located in the southern Andes and contains a number of tourist sites attracting many visitors. The capital city, also known as Ayacucho is said to have a church on every street corner. These churches were built by the Spanish in the colonial period and contain much artwork. The department is home to various Wari archeological sites. The cities and towns of Ayacucho specialize in creating and selling handicrafts. Many of the handicrafts are created in Huamanga stone a stone native to the department. The Vilcashuaman Archeological Site is an important Incan site.