Loreto, Peru - Loreto is the largest yet least populated department in Peru. Its geography is made up of dense Amazonic vegetation characterizing the type of tourism that occurs there. Iquitos, the capital, is the largest city in the Peruvian Amazon and has various touristical attractions. The city is home to European architecture brought by the rubber boom at the end of the 19th Century. One of the main attractions is the Iron House, a building designed by the French architect Gustave Eiffel who designed the Eiffel Tower as well. The city has buildings constructed during the Art Nouveau era.

The Belen district of Iquitos is in sharp contrast of the art nouveau architecture of other parts of the city. Belen lies on a series of canals and is often referred to as the Venice of the Peruvian jungle. Buildings are built atop rafts and other floatation devices to protect from flooding. Loreto's rivers contain many beautiful beaches which serve as day trips from Iquitos. The region of Loreto contains numerous National Parks as well as private reserves. These protected areas are home to an extreme diversity of animal and plant life unmatched throughout the world. These areas are served by organized guides many of which can be obtained in Lima or Iquitos.

Madre de Dios, Peru - The Madre de Dios department contains some of the most pristine virgin rainforest on the earth. The department is criss-crossed by rivers and boats are the primary mode of transport in the region. The capital, Puerto Maldonado, is also the touristical hub of the department and is a necessary stop in order to gain access to the department's national parks. The Manu National Park is the largest protected area in the department and the most diverse. It is home to 800 species of birds and 200 species of mammals. This park set the record for the greatest amount of bird sightings in one day with 324 species of birds seen.

The Tambopata Candamo National Park is the most biodiverse area in the world with the most variety of mammals, tree, insect, and bird species in the world as well as the world record for the greatest diversity among species of butterflies. Another protected area in this department is the Bahuaja-Sonene National Park. One of the reasons for touristical attraction is the lack of population in the department. The Madre de Dios department is the least populated in Peru. Because of this, the rainforest has remained almost untouched and is virgin and pristine. Accessibility to the department is easy as there are daily flights to Puerto Maldonado from Lima and Cusco. There is also a road connecting it to the Cusco department although it is being repaved as part of the Interoceanic Highway.